Monday 30th March 2026
Melbourne, Australia
Northampton, UK
IIMHE acknowledges the recent publication in the journal Osteoporosis International, examining the influence of demographic inputs on REMS-derived outputs (Chan, D., Chen, W., Yabsley, E. et al. Demographic determinants of REMS-derived BMD and fragility score. Osteoporos Int (2026). https://doi.org/10.1007/s00198-026-07960-4).
This work represents a valuable contribution to understanding how REMS performs in real-world clinical settings and reflects the ongoing scientific discussion that is essential for the evolution of any emerging technology.
While informative, the sample size (n=207) may be insufficient to fully characterise variability across diverse populations, and we welcome further evaluation through larger, multi-centre datasets. Such work will be important in strengthening the evidence base and supporting consistent clinical application.
We agree with the authors that accurate input of age, weight and other patient
demographics is fundamental to the correct use of REMS as well as DXA. REMS technology derives BMD through analysis of the ultrasound backscatter signal, generating an osteoporosis score that is interpreted against a reference population of comparable individuals, as described in the literature, hence the importance of accurate demographic data input.
Importantly, studies such as this by Chan et al., should be viewed as part of an ongoing process of research, refinement, and optimisation. Constructive scrutiny and open clinical dialogue will continue to inform REMS research and development, enhance algorithm transparency, and improve confidence in its use.
Patients who have undergone a REMS assessment, or clinicians who have received a REMS report for their patient, can be reassured that the scans remain clinically valid and should continue to be interpreted as a true reflection of bone health assessment.
Taken together, these developments support the continued advancement of REMS, with the ultimate goal of improving access to bone health assessment and strengthening understanding for both clinicians and patients.
Dr David Tognarini PhD, Director of Research
Dr Nick Birch FRCS (Orth), President
